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PubMed · 16028077

[Psoriasis SCID-mouse model].

J Pfeffer·R Kaufmann·W-H Boehncke
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Abstract

Psoriasis is characterized by a complex phenotype and pathogenesis along with polygenic determination. Several psoriasis animal models have only been able to incompletely reproduce the disease. A xenogeneic transplantation approach, grafting skin from psoriatic patients onto mice with a severe combined immunodeficiency (SCID), was the first to meet the criteria for a psoriasis model. During the last 10 years, this psoriasis SCID-mouse model not only allowed telling experiments focusing on pathogenetic aspects, but also proved being a powerful tool for drug discovery with a good predictive value.

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AnimalsDermatologic AgentsDisease Models, AnimalHumansMiceMice, SCIDPhenotypePsoriasisSevere Combined ImmunodeficiencySkinSkin TransplantationTransplantation, HeterologousComparative StudyEnglish AbstractJournal ArticleReview

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BibTeXRIS

J Pfeffer, R Kaufmann, W-H Boehncke. 2006. [Psoriasis SCID-mouse model].. https://doi.org/10.1007/s00105-005-0990-x

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