Selection and lineage specification in the thymus: commitment 4-stalled.

Amélie Collins; Dan R Littman

doi:10.1016/j.immuni.2005.07.003

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Selection and lineage specification in the thymus: commitment 4-stalled.

Amélie Collins·Dan R Littman

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Abstract

How CD4(+)CD8(+) thymocytes commit to CD4 helper versus CD8 cytotoxic lineages is a central unresolved question in developmental immunology. In this issue, show that engineering CD4 for shutoff immediately after positive selection misdirects cells to the cytotoxic lineage. The result highlights the distinction between positive selection and lineage commitment and provides new impetus for reexamining lineage models.

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Animals CD4 Antigens Cell Differentiation Cell Lineage Mice T-Lymphocytes, Cytotoxic T-Lymphocytes, Helper-Inducer Thymus Gland Journal Article Comment

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Amélie Collins, Dan R Littman. 2005. Selection and lineage specification in the thymus: commitment 4-stalled.. https://doi.org/10.1016/j.immuni.2005.07.003

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