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ROS: really involved in oxygen sensing.

William G Kaelin
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Abstract

The role of reactive oxygen species (ROS) in the cellular response to cellular oxygen sensing has been controversial. Three papers in this issue of Cell Metabolism (Brunelle et al., Guzy et al., 2005; Mansfield et al., 2005) used genetic tools to establish that ROS produced by mitochondria are required for the normal induction of HIF (hypoxia-inducible factor), which is a master regulator of oxygen-sensitive gene expression, by low oxygen.

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AnimalsDNA-Binding ProteinsHumansHypoxia-Inducible Factor 1Hypoxia-Inducible Factor 1, alpha SubunitMiceNuclear ProteinsOxygenReactive Oxygen SpeciesTranscription FactorsCommentJournal Article

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William G Kaelin. 2005. ROS: really involved in oxygen sensing.. https://doi.org/10.1016/j.cmet.2005.05.006

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