Central tolerance matters.

Ananda W Goldrath; Stephen M Hedrick

doi:10.1016/j.immuni.2005.08.004

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Central tolerance matters.

Ananda W Goldrath·Stephen M Hedrick

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Abstract

In this issue of Immunity, Anderson et al. provide another clue to the riddle that is Aire--why do human beings and mice lacking Aire develop diffuse and pathogenic autoimmunity? They find that Aire influences central tolerance not only by promoting the expression of peripheral self-proteins in thymic medullary epithelial cells (MECs) but also by furnishing these cells with the apparatus for effective antigen presentation ().

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Animals Humans Mice Polyendocrinopathies, Autoimmune Self Tolerance Transcription Factors AIRE Protein Comment Journal Article Review

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Ananda W Goldrath, Stephen M Hedrick. 2005. Central tolerance matters.. https://doi.org/10.1016/j.immuni.2005.08.004

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