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Initial computed tomography imaging experience using a new macromolecular iodinated contrast medium in experimental breast cancer.

Gerhard H Simon·Yanjun Fu·Kirill Berejnoi·Laure S Fournier·Vincenzo Lucidi·Benjamin Yeh·David M Shames·Robert C Brasch
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Abstract

OBJECTIVE: The objective of this study was to evaluate computed tomography (CT) enhancement characteristics for a new iodinated macromolecular contrast medium (MMCM), PEG12000-Gen4-triiodo, for angiographic effect and for assessment of abnormal vascular permeability in cancer. MATERIALS AND METHODS: Time persistence of angiographic effect was evaluated on rat CT images acquired over 30 minutes using the iodinated polyethyleneglycol- (PEG) based macromolecule. Dynamic CT imaging after PEG12000-Gen4-triiodo-enhancement in tumor-bearing rats was used to quantitatively estimate plasma volume and microvascular transendothelial permeability for both tumor and normal soft tissue. Using identical doses of iodine, 300 mg iodine/kg, blood curves for this MMCM and iohexol were compared. RESULTS: Serial whole-body CT angiograms using PEG12000-Gen4-triiodo showed diagnostic vascular detail through 20 minutes, and the blood enhancement curve was higher and more persistent than with small-molecular iohexol. Permeability estimates were significantly (P<0.02; paired t test) higher in tumors (48.2+/-18.1 microL/min-1 100 mL) than in muscle (2.5+/-5.7 microL/min-1 100 mL). CONCLUSIONS: Use of PEG-based MMCM for experimental CT allowed for a persistent angiographic enhancement and for quantitative estimation of tumor microvascular characteristics.

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AnimalsContrast MediaDendrimersFemaleIohexolMacromolecular SubstancesMammary Neoplasms, ExperimentalMolecular StructurePolyethylene GlycolsRatsRats, Sprague-DawleyTomography, X-Ray ComputedJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S.

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Gerhard H Simon, Yanjun Fu, Kirill Berejnoi, Laure S Fournier, Vincenzo Lucidi, Benjamin Yeh, David M Shames, Robert C Brasch. 2005. Initial computed tomography imaging experience using a new macromolecular iodinated contrast medium in experimental breast cancer.. https://doi.org/10.1097/01.rli.0000174477.11541.ce

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