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PubMed · 16181848

Primary pulmonary lymphoma.

Brian B Graham·Douglas J Mathisen·Eugene J Mark·Ronald W Takvorian
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Abstract

BACKGROUND: Primary pulmonary lymphoma is a rare disease. The clinical characteristics, methods of treatment, and outcomes are not well elucidated. METHODS: A retrospective review of primary pulmonary lymphoma cases at a single institution from 1990 to 2002 was performed. RESULTS: Eighteen patients were included, with a mean follow-up of 2.9 years. Fourteen patients had mucosa-associated lymphoid tissue (MALT) lymphoma, 2 had large cell transformation of sheet cells in MALT lymphoma, and 1 each had Hodgkin's disease and follicular lymphoma. Computed tomography-guided biopsy was diagnostic in only two of eight attempts. Eleven patients had disease confined to the pulmonary parenchyma, and 7 had parenchymal disease as well as mediastinal lymphadenopathy. Treatment methods included observation only (n = 1), surgery only (n = 6), surgery plus chemotherapy (n = 8), surgery plus radiotherapy (n = 1), and surgery plus chemotherapy plus radiotherapy (n = 2). Kaplan-Meier estimate of median time to disease recurrence or death was 6 years. Only 1 patient died of disease-related causes. Patients who had bilateral disease were more likely to have recurrent disease or death (p = 0.03). CONCLUSIONS: A wide range of treatments were used for patients with generally MALT lymphoma, resulting in good outcomes, and recurrent disease was well controlled.

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AdultAgedAged, 80 and overChemotherapy, AdjuvantFemaleFollow-Up StudiesHodgkin DiseaseHumansLung NeoplasmsLymphomaLymphoma, B-Cell, Marginal ZoneLymphoma, FollicularMaleMiddle AgedNeoplasm StagingPrognosisRadiographyRadiotherapy, AdjuvantRetrospective StudiesSurvival AnalysisTreatment OutcomeJournal Article

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Brian B Graham, Douglas J Mathisen, Eugene J Mark, Ronald W Takvorian. 2005. Primary pulmonary lymphoma.. https://doi.org/10.1016/j.athoracsur.2005.04.014

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