Rapamycin analogs with reduced systemic exposure.

Rolf Wagner; Karl W Mollison; Luping Liu; Cynthia L Henry; Teresa A Rosenberg; Nwe Bamaung; Noah Tu; Paul E Wiedeman; Yatsun Or; Jay R Luly; Benjamin C Lane; James Trevillyan; Yung-Wu Chen; Thomas Fey; Gin Hsieh; Kennan Marsh; Merrill Nuss; Peer B Jacobson; Denise Wilcox; Richard P Carlson; George W Carter; Stevan W Djuric

doi:10.1016/j.bmcl.2005.06.106

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PubMed · 16185865

Rapamycin analogs with reduced systemic exposure.

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Abstract

The synthesis and biological activities of rapamycin (I) analogs modified at the C-40 position are reported. Emphasis placed on compounds that potentially have an improved safety profile on account of their shorter in vivo half-life when compared with rapamycin.

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Animals Antirheumatic Agents Arthritis, Rheumatoid Male Radiography Rats Rats, Inbred Lew Rats, Sprague-Dawley Sirolimus Journal Article

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Rolf Wagner, Karl W Mollison, Luping Liu, Cynthia L Henry, Teresa A Rosenberg, Nwe Bamaung, Noah Tu, Paul E Wiedeman, Yatsun Or, Jay R Luly, Benjamin C Lane, James Trevillyan, Yung-Wu Chen, Thomas Fey, Gin Hsieh, Kennan Marsh, Merrill Nuss, Peer B Jacobson, Denise Wilcox, Richard P Carlson, George W Carter, Stevan W Djuric. 2005-09-26. Rapamycin analogs with reduced systemic exposure.. https://doi.org/10.1016/j.bmcl.2005.06.106

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