Growing roles for the mTOR pathway.

Dos D Sarbassov; Siraj M Ali; David M Sabatini

doi:10.1016/j.ceb.2005.09.009

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Growing roles for the mTOR pathway.

Dos D Sarbassov·Siraj M Ali·David M Sabatini

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Abstract

The mammalian TOR (mTOR) pathway is a key regulator of cell growth and proliferation and increasing evidence suggests that its deregulation is associated with human diseases, including cancer and diabetes. The mTOR pathway integrates signals from nutrients, energy status and growth factors to regulate many processes, including autophagy, ribosome biogenesis and metabolism. Recent work identifying two structurally and functionally distinct mTOR-containing multiprotein complexes and TSC1/2, rheb, and AMPK as upstream regulators of mTOR is beginning to reveal how mTOR can sense diverse signals and produce a myriad of responses.

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Animals Disease Humans Models, Biological Neoplasms Phosphatidylinositol 3-Kinases Protein Kinases Proto-Oncogene Proteins c-akt Signal Transduction TOR Serine-Threonine Kinases Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

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Dos D Sarbassov, Siraj M Ali, David M Sabatini. 2005-10-13. Growing roles for the mTOR pathway.. https://doi.org/10.1016/j.ceb.2005.09.009

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