Inflammatory granulocytes decrease subcutaneous growth of melanoma in mice.

Madalena M Costa; Artur P Aguas

doi:10.1007/s10753-004-6646-7

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PubMed · 16245078

Inflammatory granulocytes decrease subcutaneous growth of melanoma in mice.

Madalena M Costa·Artur P Aguas

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Abstract

Growing melanomas invade the subcutaneous tissues. We have compared the size of tumors implanted in the subcutaneous cavities of C57BL/6 mice where inflammatory reactions were induced before the injection of 5 x 10(5) melanoma cells (B16F10 cell line). Granulocytic inflammation of the subcutaneous cavities resulted in a significant decrease in the growth of the implanted melanomas, whereas monocytic inflammation had no effect on tumor growth. We conclude that granulocytes, but not monocytes/macrophages, have anti-tumor action on melanoma that invade the subcutaneous tissues.

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Animals Cattle Cell Line, Tumor Exudates and Transudates Female Granulocytes Inflammation Injections, Subcutaneous Melanoma, Experimental Mice Mice, Inbred C57BL Neoplasm Transplantation Serum Albumin, Bovine Skin Neoplasms Time Factors Tumor Burden Comparative Study Journal Article Research Support, Non-U.S. Gov't

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Madalena M Costa, Artur P Aguas. 2004. Inflammatory granulocytes decrease subcutaneous growth of melanoma in mice.. https://doi.org/10.1007/s10753-004-6646-7

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