Design of multi-centre trials with binary response.

Vladimir Dragalin; Valerii Fedorov

doi:10.1002/sim.2406

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Design of multi-centre trials with binary response.

Vladimir Dragalin·Valerii Fedorov

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Abstract

We propose a correlated beta-binomial model for the binary response in multi-centre trials. The likelihood function in this case has a closed-form and we avoid multivariate numerical integrations in determining the maximum likelihood estimator. Based on derived asymptotic variance-covariance matrix of the MLE, we obtain relatively simple formulae that relate the number of centres, the total number of patients and the precision of the parameter estimate.

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Vladimir Dragalin, Valerii Fedorov. 2006-08-30. Design of multi-centre trials with binary response.. https://doi.org/10.1002/sim.2406

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