Fast-melting tablets based on highly plastic granules.

Yourong Fu; Seong Hoon Jeong; Kinam Park

doi:10.1016/j.jconrel.2005.09.021

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Fast-melting tablets based on highly plastic granules.

Yourong Fu·Seong Hoon Jeong·Kinam Park

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Abstract

Highly plastic granules that can be compressed into tablets at low pressure were developed to make fast-melting tablets (FMTs) by compression method. The highly plastic granules are composed of three components: a plastic material, a material enhancing water penetration, and a wet binder. One of the unique properties of the highly plastic granules is that they maintain a porous structure even after compression into tablets. The porous and plastic nature of the granules allows fast absorption of water into the compressed tablet for fast melting/dissolution of the tablet. The prepared tablets possess tablet strength and friability that are suitable for multi-tablet packages. The three-component highly plastic granules provide an effective way of making FMTs by compression.

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Chemistry, Pharmaceutical Excipients Hardness Microscopy, Electron, Scanning Particle Size Permeability Plastics Powders Solubility Tablets Water Journal Article Research Support, Non-U.S. Gov't

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Yourong Fu, Seong Hoon Jeong, Kinam Park. 2005-11-02. Fast-melting tablets based on highly plastic granules.. https://doi.org/10.1016/j.jconrel.2005.09.021

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