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Snaring the function of alpha-synuclein.

Nancy M Bonini·Benoit I Giasson
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Abstract

It is well established that the abundant neuronal protein alpha-synuclein has a causal role in Parkinson's disease, yet the normal functions of this protein remain unclear. In this issue of Cell, Chandra et al. (2005) reveal that alpha-synuclein acts as a molecular chaperone, assisting in the folding and refolding of synaptic proteins called SNAREs. These proteins are crucial for release of neurotransmitters at the neuronal synapse, vesicle recycling, and synaptic integrity.

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AnimalsHSP40 Heat-Shock ProteinsHumansMolecular ChaperonesMutationNeuronsParkinson DiseaseProtein FoldingProtein TransportSNARE ProteinsSynapsesSynaptic Vesiclesalpha-SynucleinCommentJournal Article

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Nancy M Bonini, Benoit I Giasson. 2005-11-04. Snaring the function of alpha-synuclein.. https://doi.org/10.1016/j.cell.2005.10.017

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