RNAi: RISC gets loaded.

Jonathan B Preall; Erik J Sontheimer

doi:10.1016/j.cell.2005.11.006

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RNAi: RISC gets loaded.

Jonathan B Preall·Erik J Sontheimer

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Abstract

When an siRNA or miRNA proceeds through the RNA-induced silencing complex assembly pathway, only one of the two approximately 21-nucleotide RNA strands survives in the final, active complex. In this issue of Cell, Matranga et al. (2005) and Rand et al. (2005) reveal the fate of the rejected passenger siRNA strand. Additionally, Gregory et al. (2005) define a heterotrimeric complex from humans that appears to execute dsRNA loading, strand selection, and target mRNA cleavage activities.

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Animals Argonaute Proteins Drosophila Proteins Drosophila melanogaster Humans MicroRNAs Models, Genetic RNA Interference RNA, Double-Stranded RNA, Small Interfering RNA-Induced Silencing Complex Comment Journal Article

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Jonathan B Preall, Erik J Sontheimer. 2005-11-18. RNAi: RISC gets loaded.. https://doi.org/10.1016/j.cell.2005.11.006

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