Testing and estimation in flexible group sequential designs with adaptive treatment selection.

Martin Posch; Franz Koenig; Michael Branson; Werner Brannath; Cornelia Dunger-Baldauf; Peter Bauer

doi:10.1002/sim.2389

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Testing and estimation in flexible group sequential designs with adaptive treatment selection.

Martin Posch·Franz Koenig·Michael Branson·Werner Brannath·Cornelia Dunger-Baldauf·Peter Bauer

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Abstract

Integrating selection and confirmation phases into a single trial can expedite the development of new treatments and allows to use all accumulated data in the decision process. In this paper we review adaptive treatment selection based on combination tests and propose overall adjusted p-values and simultaneous confidence intervals. Also point estimation in adaptive trials is considered. The methodology is illustrated in a detailed example based on an actual planned study.

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Austria Clinical Trials as Topic Confidence Intervals Humans Models, Statistical Research Design Therapies, Investigational Journal Article Research Support, Non-U.S. Gov't

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Martin Posch, Franz Koenig, Michael Branson, Werner Brannath, Cornelia Dunger-Baldauf, Peter Bauer. 2005-12-30. Testing and estimation in flexible group sequential designs with adaptive treatment selection.. https://doi.org/10.1002/sim.2389

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