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CaMKII structure--an elegant design.

Tony Hunter·Howard Schulman
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Abstract

Crystal structures of protein kinases continue to reveal new mechanisms for the regulation of catalytic activity of these enzymes. In this issue of Cell, Rosenberg et al. (2005) report the structure of the catalytic and regulatory domains of CaMKII, a protein kinase important in the cellular response to changes in intracellular calcium ion concentration. This study provides new mechanistic insights into the workings of this finely tuned molecular machine.

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AnimalsCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium-Calmodulin-Dependent Protein KinasesCalmodulinCatalytic DomainCrystallography, X-RayProtein Structure, QuaternaryProtein SubunitsCommentJournal Article

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Tony Hunter, Howard Schulman. 2005-12-02. CaMKII structure--an elegant design.. https://doi.org/10.1016/j.cell.2005.11.017

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