Clamp loaders and replication initiation.

Mike O'Donnell; John Kuriyan

doi:10.1016/j.sbi.2005.12.004

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Clamp loaders and replication initiation.

Mike O'Donnell·John Kuriyan

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Abstract

Clamp loaders are ATP-driven multiprotein machines that couple ATP hydrolysis to the opening and closing of a circular protein ring around DNA. This ring-shaped clamp slides along DNA, and interacts with numerous proteins involved in DNA replication, DNA repair and cell cycle control. Recently determined structures of clamp loader complexes from prokaryotic and eukaryotic sources have revealed exciting new details of how these complex AAA+ machines perform this essential clamp loading function.

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Adenosine Triphosphate DNA Replication DNA, Bacterial DNA, Fungal Escherichia coli Proteins Humans Multiprotein Complexes Saccharomyces cerevisiae Proteins Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

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Mike O'Donnell, John Kuriyan. 2006-01-11. Clamp loaders and replication initiation.. https://doi.org/10.1016/j.sbi.2005.12.004

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