Building addressable libraries: spatially isolated, chip-based reductive amination reactions.

Eden Tesfu; Karl Maurer; Kevin D Moeller

doi:10.1021/ja057155x

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Building addressable libraries: spatially isolated, chip-based reductive amination reactions.

Eden Tesfu·Karl Maurer·Kevin D Moeller

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Abstract

A Pd(II) reagent has been generated at preselected sites on an electrochemically addressable chip and used to effect the oxidation of the neighboring alcohols on the polymer coating the chip's surface. The resulting carbonyls were then used to accomplish site-selective reductive amination reactions on the chips. The work demonstrates that the confinement strategy developed for spatially isolated Wacker oxidations to specific sites on the chips is general and can be used for other Pd(II)-based reactions.

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Alcohols Amination Amines Ethyl Ethers Oxidation-Reduction Palladium Semiconductors Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

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Eden Tesfu, Karl Maurer, Kevin D Moeller. 2006-01-11. Building addressable libraries: spatially isolated, chip-based reductive amination reactions.. https://doi.org/10.1021/ja057155x

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