The DDAH-ADMA-NOS pathway.

James M Leiper

doi:10.1097/01.ftd.0000179849.42395.11

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The DDAH-ADMA-NOS pathway.

James M Leiper

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Abstract

An increasing number of reports in the literature indicate that endogenously produced inhibitors of nitric oxide synthase (NOS),particularly asymmetric dimethylarginine (ADMA), regulate nitric oxide generation in disease states. This article describes the biology of ADMA and the implications for cardiovascular physiology and pathophysiology.

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Amidohydrolases Arginine Cardiovascular Diseases Endothelium, Vascular Enzyme Inhibitors Humans Models, Biological Nitric Oxide Nitric Oxide Synthase Risk Factors Journal Article Research Support, Non-U.S. Gov't

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James M Leiper. 2005. The DDAH-ADMA-NOS pathway.. https://doi.org/10.1097/01.ftd.0000179849.42395.11

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