Imidazo[1,2-a]pyrimidines as functionally selective GABA(A) ligands.

Wesley P Blackaby; John R Atack; Frances Bromidge; José L Castro; Simon C Goodacre; David J Hallett; Richard T Lewis; George R Marshall; Andrew Pike; Alison J Smith; Leslie J Street; David F D Tattersall; Keith A Wafford

doi:10.1016/j.bmcl.2005.11.112

PubMed · 16406613

Imidazo[1,2-a]pyrimidines as functionally selective GABA(A) ligands.

Wesley P Blackaby·John R Atack·Frances Bromidge·José L Castro·Simon C Goodacre·David J Hallett·Richard T Lewis·George R Marshall·Andrew Pike·Alison J Smith·Leslie J Street·David F D Tattersall·Keith A Wafford

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Abstract

Imidazo[1,2-a]pyrimidines are GABA(A) receptor benzodiazepine binding site ligands which can exhibit functional selectivity for the alpha(3) subtype over the alpha(1) subtype. SAR studies to optimize this functional selectivity are described.

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Imidazoles Ligands Molecular Structure Pyrimidines Receptors, GABA-A Sensitivity and Specificity Structure-Activity Relationship Substrate Specificity Journal Article

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Wesley P Blackaby, John R Atack, Frances Bromidge, José L Castro, Simon C Goodacre, David J Hallett, Richard T Lewis, George R Marshall, Andrew Pike, Alison J Smith, Leslie J Street, David F D Tattersall, Keith A Wafford. 2006-01-06. Imidazo[1,2-a]pyrimidines as functionally selective GABA(A) ligands.. https://doi.org/10.1016/j.bmcl.2005.11.112

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