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(P)PARsing epidermal development.

Sandrine Dubrac·Matthias Schmuth
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Abstract

Overexpression of PPAR-alpha, a developmental transcription factor important in epidermal embryogenesis, in basal keratinocytes causes epidermal thinning when activated constitutively during development, but not if activated in adults; and lack of PPAR-alpha transiently delays stratum corneum formation within a window late in epidermal development (day 18.5 to birth). In contrast, pharmacologic activation of PPAR-alpha inhibits proliferation and induces differentiation in mouse epidermis regardless of developmental stage. Thus, PPAR-alpha is an important regulator of epidermal homeostasis.

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AnimalsCell DifferentiationCell ProliferationEpidermisKeratinocytesMicePPAR alphaTranscriptional ActivationCommentJournal Article

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Sandrine Dubrac, Matthias Schmuth. 2006. (P)PARsing epidermal development.. https://doi.org/10.1038/sj.jid.5700137

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