Establishment and functioning of intrathymic microenvironments.

Graham Anderson; William E Jenkinson; Terry Jones; Sonia M Parnell; Francesca A M Kinsella; Andrea J White; Judit E Pongrac'z; Simona W Rossi; Eric J Jenkinson

doi:10.1111/j.0105-2896.2006.00347.x

PubMed · 16448531

Establishment and functioning of intrathymic microenvironments.

Graham Anderson·William E Jenkinson·Terry Jones·Sonia M Parnell·Francesca A M Kinsella·Andrea J White·Judit E Pongrac'z·Simona W Rossi·Eric J Jenkinson

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Abstract

The thymus supports the production of self-tolerant T cells from immature precursors. Studying the mechanisms regulating the establishment and maintenance of stromal microenvironments within the thymus therefore is essential to our understanding of T-cell production and ultimately immune system functioning. Despite our ability to phenotypically define stromal cell compartments of the thymus, the mechanisms regulating their development and the ways by which they influence T-cell precursors are still unclear. Here, we review recent findings and highlight unresolved issues relating to the development and functioning of thymic stromal cells.

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Animals Cell Communication Cell Differentiation Dendritic Cells Epithelial Cells Humans Mesoderm Models, Immunological Organogenesis Self Tolerance Signal Transduction Stromal Cells T-Lymphocyte Subsets Thymus Gland Journal Article Review

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Graham Anderson, William E Jenkinson, Terry Jones, Sonia M Parnell, Francesca A M Kinsella, Andrea J White, Judit E Pongrac'z, Simona W Rossi, Eric J Jenkinson. 2006. Establishment and functioning of intrathymic microenvironments.. https://doi.org/10.1111/j.0105-2896.2006.00347.x

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