Langerhans cells--revisiting the paradigm using genetically engineered mice.

Adrien Kissenpfennig; Bernard Malissen

doi:10.1016/j.it.2006.01.003

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Langerhans cells--revisiting the paradigm using genetically engineered mice.

Adrien Kissenpfennig·Bernard Malissen

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Abstract

Langerhans cells (LCs) are prominent dendritic cells (DCs) in epithelia, but their role in immunity and tolerance is poorly defined. 'Knockin' mice expressing enhanced green fluorescent protein (EGFP) under the control of the langerin (CD207) gene were recently developed in order to discriminate epidermal LCs from other DC subsets and at the same time to track their dynamics under steady-state or inflammatory conditions in vivo. Additional knockin mice expressing a diphtheria toxin receptor fused to EGFP were used to conditionally ablate LCs and assess their role in triggering hapten-specific T cell effectors through skin immunization. We review the insights that have been provided by these various knockin mice and discuss gaps in our knowledge of LCs that need to be filled.

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Animals Dendritic Cells Dermatitis, Contact Immunity, Cellular Langerhans Cells Lymph Nodes Mice Mice, Transgenic Skin Spleen T-Lymphocytes Journal Article Research Support, Non-U.S. Gov't Review

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Adrien Kissenpfennig, Bernard Malissen. 2006-02-03. Langerhans cells--revisiting the paradigm using genetically engineered mice.. https://doi.org/10.1016/j.it.2006.01.003

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