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Class switch recombination: an emerging mechanism.

A L Kenter
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Abstract

Class switch recombination (CSR) has been the least well understood of the Ig gene DNA rearrangements. The discovery that activation-induced deaminase (AID) is a pivotal player in CSR as well as somatic hypermutation (SHM) and its variant, gene conversion, represents a sea change in our understanding of these processes. The recognition that AID directly deaminates ssDNA has provided a springboard toward the emergence of a model that explains the initiation of these events. Nonhomologous end joining (NHEJ), the main pathway for the repair of double-strand breaks in mammalian cells plays a key role in the resolution of CSR transactions. Mediators of general double-strand break repair are also involved in CSR and are mutated in several immunodeficiency diseases. A global picture of the mechanism of CSR is emerging and is providing new insights toward understanding the genetic events that underlie B cell cancers.

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AnimalsCytidine DeaminaseGenes, ImmunoglobulinHumansImmunoglobulin Class SwitchingImmunoglobulin Switch RegionMiceRecombination, GeneticAICDA (Activation-Induced Cytidine Deaminase)Journal ArticleResearch Support, N.I.H., ExtramuralReview

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A L Kenter. 2005. Class switch recombination: an emerging mechanism.. https://doi.org/10.1007/3-540-26363-2_8

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