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Complex networks orchestrate epithelial-mesenchymal transitions.

Jean Paul Thiery·Jonathan P Sleeman
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Abstract

Epithelial-mesenchymal transition is an indispensable mechanism during morphogenesis, as without mesenchymal cells, tissues and organs will never be formed. However, epithelial-cell plasticity, coupled to the transient or permanent formation of mesenchyme, goes far beyond the problem of cell-lineage segregation. Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.

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AnimalsCell DifferentiationEmbryonic DevelopmentEpithelial CellsGastrulaHeart ValvesHumansMesodermMiceNeoplasmsSignal TransductionJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Jean Paul Thiery, Jonathan P Sleeman. 2006. Complex networks orchestrate epithelial-mesenchymal transitions.. https://doi.org/10.1038/nrm1835

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