A long-distance relationship between RNAi and Polycomb.

Elissa P Lei; Victor G Corces

doi:10.1016/j.cell.2006.02.026

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A long-distance relationship between RNAi and Polycomb.

Elissa P Lei·Victor G Corces

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Abstract

RNA interference (RNAi) pathways can result in sequence-specific transcriptional gene silencing on the level of chromatin. In this issue of Cell, Grimaud et al. (2006) reveal that the RNAi machinery is required for long-distance physical interactions between chromosomes mediated by the Polycomb repressive complex. These results suggest that the RNAi machinery may regulate higher-order nuclear organization.

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Cell Nucleus Chromosomes Drosophila Proteins Gene Expression Regulation Gene Silencing Models, Genetic Polycomb Repressive Complex 1 RNA Interference Signal Transduction Journal Article Comment

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Elissa P Lei, Victor G Corces. 2006-03-10. A long-distance relationship between RNAi and Polycomb.. https://doi.org/10.1016/j.cell.2006.02.026

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