TOPping up ATR activity.

Jiri Bartek; Niels Mailand

doi:10.1016/j.cell.2006.02.029

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TOPping up ATR activity.

Jiri Bartek·Niels Mailand

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Abstract

The nuclear protein kinase ATR is a key regulator of genome integrity that functions at checkpoints for damaged or incompletely replicated DNA. In this issue of Cell, Kumagai et al. (2006) shed light on the molecular mechanism that controls ATR. They report that a physical interaction between ATR and a distinct domain of TopBP1 greatly enhances ATR kinase activity.

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Animals Ataxia Telangiectasia Mutated Proteins Carrier Proteins Cell Cycle Proteins DNA Repair DNA-Binding Proteins Enzyme Activation Gene Expression Regulation Humans Models, Genetic Nuclear Proteins Protein Serine-Threonine Kinases Xenopus Proteins Journal Article Comment

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Jiri Bartek, Niels Mailand. 2006-03-10. TOPping up ATR activity.. https://doi.org/10.1016/j.cell.2006.02.029

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