Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device.

James H Prescott; Sara Lipka; Samuel Baldwin; Norman F Sheppard; John M Maloney; Jonathan Coppeta; Barry Yomtov; Mark A Staples; John T Santini

doi:10.1038/nbt1199

PubMed · 16531991

Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device.

James H Prescott·Sara Lipka·Samuel Baldwin·Norman F Sheppard·John M Maloney·Jonathan Coppeta·Barry Yomtov·Mark A Staples·John T Santini

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Abstract

Implanted drug delivery systems are being increasingly used to realize the therapeutic potential of peptides and proteins. Here we describe the controlled pulsatile release of the polypeptide leuprolide from microchip implants over 6 months in dogs. Each microchip contains an array of discrete reservoirs from which dose delivery can be controlled by telemetry.

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Animals Dogs Drug Therapy, Computer-Assisted Equipment Design Equipment Failure Analysis Infusion Pumps, Implantable Leuprolide Male Microfluidic Analytical Techniques Miniaturization Telemetry Journal Article

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James H Prescott, Sara Lipka, Samuel Baldwin, Norman F Sheppard, John M Maloney, Jonathan Coppeta, Barry Yomtov, Mark A Staples, John T Santini. 2006-03-12. Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device.. https://doi.org/10.1038/nbt1199

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