Adynamic bone revisited: is there progress?

Cheryl P Sanchez

PubMed · 16538874

Adynamic bone revisited: is there progress?

Abstract

Adynamic or aplastic bone remains an important medical issue in children with chronic renal failure. To prevent the development of adynamic bone during treatment of secondary hyperparathyroidism, clinical recommendations have been made to maintain intact PTH levels at 2 to 4 times the normal values, avoid hypercalcemia, and keep serum phosphorus levels within age-appropriate limits in children with chronic renal failure. Less-calcemic vitamin D analogs and calcium-free and aluminum-free phosphate-binding agents should be used in children who can tolerate these agents. It is important to remember to reduce or discontinue any medication, whether it is vitamin D, a calcium salt, or any other agent that significantly lowers PTH, especially when intact PTH levels decline rapidly (to < 150 pg/mL) and serum calcium levels are higher than 10 mg/dL.

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Biomarkers Calcium Chronic Kidney Disease-Mineral and Bone Disorder Disease Progression Humans Kidney Failure, Chronic Parathyroid Hormone Risk Factors Vitamin D Journal Article Review Comment

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Cheryl P Sanchez. Adynamic bone revisited: is there progress?. https://pubmed.ncbi.nlm.nih.gov/16538874/

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