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Increasing yield also increases false positives and best serves to exclude GERD.

Jason Connor·Joel Richter
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Abstract

Multiple diagnostic tests always improve diagnostic yield. However, with the addition of more true positives come more false positives. Therefore, positive predictive values likely decrease with additional testing. We show this is true even when no gold standard exists to verify the dual testing's sensitivity and specificity.

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Anti-Ulcer AgentsGastric Acidity DeterminationGastroesophageal RefluxHumansMonitoring, AmbulatoryPredictive Value of TestsProton Pump InhibitorsSensitivity and SpecificityStatistics as TopicCommentComparative StudyEditorial

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Jason Connor, Joel Richter. 2006. Increasing yield also increases false positives and best serves to exclude GERD.. https://doi.org/10.1111/j.1572-0241.2006.00555.x

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