Cellular conference call: external feedback affects cell-fate decisions.

Alexander Loewer; Galit Lahav

doi:10.1016/j.cell.2006.03.010

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Cellular conference call: external feedback affects cell-fate decisions.

Alexander Loewer·Galit Lahav

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Abstract

Cells often need to respond to multiple opposing signals simultaneously. In this issue of Cell, it is shown that challenging cells with multiple extracellular signals induces an external feedback that involves the release of and response to additional secreted factors with antagonistic functions. These results suggest that an individual cell's decision to die or survive is not wholly independent but depends, at least in part, on feedback from its neighbors.

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Animals Apoptosis Cell Survival Epidermal Growth Factor Feedback, Physiological Humans Signal Transduction Tumor Necrosis Factors Comment Journal Article Review

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Alexander Loewer, Galit Lahav. 2006-03-24. Cellular conference call: external feedback affects cell-fate decisions.. https://doi.org/10.1016/j.cell.2006.03.010

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