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PubMed · 16572389

Tolls for B cells.

Simon Fillatreau·Rudolf A Manz
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Abstract

Priming of naive lymphocytes is important for yielding efficient immune responses. Mechanisms controlling this process are also important for preventing immune cells from attacking self-antigens. It is well known that signals provided by innate immune receptors, such as Toll-like receptors (TLR), are essential to induce dendritic cell maturation that subsequently allows the priming of naive T cells. In this issue of the European Journal of Immunology, it is shown that TLR stimulation effectively potentiates naive human B cell activation and production of antibodies in T-dependent immune responses. TLR signals can be delivered to B cells directly, or indirectly via cytokines provided by TLR-activated dendritic cells.

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AnimalsB-LymphocytesHumansLymphocyte ActivationSignal TransductionToll-Like ReceptorsCommentJournal ArticleReview

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Simon Fillatreau, Rudolf A Manz. 2006. Tolls for B cells.. https://doi.org/10.1002/eji.200636040

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