Thionation using fluorous Lawesson's reagent.

Zoltán Kaleta; Brian T Makowski; Tibor Soós; Roman Dembinski

doi:10.1021/ol060208a

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Thionation using fluorous Lawesson's reagent.

Zoltán Kaleta·Brian T Makowski·Tibor Soós·Roman Dembinski

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Abstract

[reaction: see text] Thionation of amides, 1,4-diketones, N-(2-oxoalkyl)amides, N,N'-acylhydrazines, and acyl-protected uridines with the use of a fluorous analogue of the Lawesson's reagent leads to thioamides, thiophenes, 1,3-thiazoles, 1,3,4-thiadiazoles, and acyl-protected 4-thiouridines. The isolation of the final products in high yields is achieved in most cases by a simple filtration (fluorous solid-phase extraction).

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Combinatorial Chemistry Techniques Indicators and Reagents Molecular Structure Organothiophosphorus Compounds Sulfur Compounds Thiazoles Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

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Zoltán Kaleta, Brian T Makowski, Tibor Soós, Roman Dembinski. 2006-04-13. Thionation using fluorous Lawesson's reagent.. https://doi.org/10.1021/ol060208a

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