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Age as a determinant factor for endotoxin induced uveitis.

Beatriz E Brito·Junedy C Marcano·Eva Salazar·Marisol Cano·Leslie Baute·Geraldine Bernal·Luis R Gonzalez
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Abstract

PURPOSE: To determine if susceptibility to systemic endotoxin-induced uveitis is an age-related phenomenon in the rabbit. METHODS: Young and adult rabbits were injected intravenously with 2.5 microg/kg of E. coli endotoxin or saline. Thereafter, the number of exudating cells at 2, 6, 12, 24 and 48 hours were determined. The levels of lipopolysaccharide-binding protein, total protein, prostaglandin-E2, nitric oxide and interleukin-6 in aqueous humor were also determined 24 hours after the injections. RESULTS: A significant increase in the number of exudating cells and the levels of lipopolysaccharide-binding protein, total protein, prostaglandin-E2 and nitric oxide in aqueous humor was observed only in adult rabbits 24 hours after endotoxin injection. No differences were observed in the increased IL-6 levels. CONCLUSIONS: Life stage seems to be a critical factor in developing an eye-inflammatory response induced by systemic endotoxin. This could be a consequence of a differential specific activation of the ocular immune response.

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Age FactorsAgingAnimalsAqueous HumorBiomarkersDinoprostoneDisease Models, AnimalEye ProteinsInterleukin-6LipopolysaccharidesNeutrophilsNitric OxideRabbitsUveitisComparative StudyJournal Article

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Beatriz E Brito, Junedy C Marcano, Eva Salazar, Marisol Cano, Leslie Baute, Geraldine Bernal, Luis R Gonzalez. 2006. Age as a determinant factor for endotoxin induced uveitis.. https://doi.org/10.1080/09273940500328503

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