New battlefields for costimulation.

Natalia Martin-Orozco; Chen Dong

doi:10.1084/jem.20060219

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New battlefields for costimulation.

Natalia Martin-Orozco·Chen Dong

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Abstract

Costimulation regulates the activation of naive T cells as they first encounter antigens in the secondary lymphoid organs. But recently characterized costimulatory molecules of the B7 family appear to have roles beyond initial T cell activation. New evidence shows that negative costimulators expressed by tumors and normal tissues afford local protection from T cell-mediated attack.

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Animals Humans Lymphocyte Activation T-Lymphocytes Comment Journal Article Research Support, N.I.H., Extramural Review

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Natalia Martin-Orozco, Chen Dong. 2006-04-10. New battlefields for costimulation.. https://doi.org/10.1084/jem.20060219

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