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Timed-release depot for anticancer agents.

S Yolles·T D Leafe·F J Meyer
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Abstract

The timed-release of anticancer agents from composities with poly (lactic acid) was studied in rats. In the case of cyclophosphamide-poly (lactic acid) composites, 67% of the administered dose was released within 34 days. With cis-dichlorodiammineplatinum (II), the amount of drug released was only 9.3% within the same period. This difference might be attributed to the different solubilities of these two drugs in the polymer. Electron spectroscopy chemical analysis, a new tool, was used to investigate the extent of diffusion of drugs in polymer films.

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AnimalsAntineoplastic AgentsCisplatinCyclophosphamideDelayed-Action PreparationsElectron Spin Resonance SpectroscopyLactatesMaleNitrogenPhosphorusPlatinumPolymersRatsTime FactorsJournal Article

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S Yolles, T D Leafe, F J Meyer. 1975. Timed-release depot for anticancer agents.. https://doi.org/10.1002/jps.2600640124

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