Resin-bound dynamic combinatorial chemistry.

Brian R McNaughton; Benjamin L Miller

doi:10.1021/ol060330+

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Resin-bound dynamic combinatorial chemistry.

Brian R McNaughton·Benjamin L Miller

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Abstract

[reaction: see text] Dynamic combinatorial chemistry (DCC) is a promising technique for receptor-aided selection of high-affinity ligands from equilibrating combinatorial libraries. Identification of the specific ligand(s) selected is often challenging, however, due to difficulties associated with chromatographic separation and/or mass degeneracy within the library. Herein, we describe proof-of-concept experiments demonstrating a new technique termed resin-bound DCC (RB-DCC), which provides a solution to this problem.

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Base Sequence Binding Sites Combinatorial Chemistry Techniques DNA Drug Design Molecular Structure Polystyrenes Journal Article Research Support, Non-U.S. Gov't

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Brian R McNaughton, Benjamin L Miller. 2006-04-27. Resin-bound dynamic combinatorial chemistry.. https://doi.org/10.1021/ol060330%2B

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