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Nonmodulation and essential hypertension.

Norman K Hollenberg·Gordon H Williams
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Abstract

Nonmodulation is a process in which there is a disorder in angiotensin-dependent control of the renal circulation and adrenal aldosterone release. The abnormalities are associated with an inability to handle a sodium load and salt-sensitive hypertension. All of the features are corrected by angiotensin-converting enzyme inhibition. A striking family history of hypertension and concordance of responses to angiotensin II in sibling pairs have suggested a familial factor. Genes governing renin substrate (angiotensinogen) production showed gene polymorphisms in nonmodulators. As nonmodulation occurs in approximately 40% of patients with essential hypertension, clearly other genes must contribute.

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Angiotensin-Converting Enzyme InhibitorsAngiotensinogenHumansHypertensionKidneyPeptidyl-Dipeptidase APolymorphism, GeneticRenal CirculationReninRenin-Angiotensin SystemSodiumJournal ArticleReview

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Norman K Hollenberg, Gordon H Williams. 2006. Nonmodulation and essential hypertension.. https://doi.org/10.1007/s11906-006-0008-9

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