Ewing's sarcoma: general insights from a rare model.

Sean Davis; Paul S Meltzer

doi:10.1016/j.ccr.2006.05.003

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Ewing's sarcoma: general insights from a rare model.

Sean Davis·Paul S Meltzer

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Abstract

Ewing's sarcoma is characterized by the presence of fusion oncoproteins involving EWSR1 and an ETS gene, most commonly FLI1. In this issue of Cancer Cell, Smith et al. have combined RNA interference with expression profiling to study the pattern of gene expression downstream of the most common of these fusions, EWS/FLI. Using this strategy, Smith et al. have identified a homeobox gene, NKX2.2, which is both highly expressed in Ewing's sarcoma and essential for the transforming activity of EWS/FLI.

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Animals Cell Transformation, Neoplastic Gene Expression Regulation, Neoplastic Homeobox Protein Nkx-2.2 Homeodomain Proteins Mice Models, Biological Nuclear Proteins Oncogene Proteins, Fusion Proto-Oncogene Protein c-fli-1 RNA-Binding Protein EWS Sarcoma, Ewing Transcription Factors Zebrafish Proteins Journal Article Research Support, Non-U.S. Gov't Comment

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Sean Davis, Paul S Meltzer. 2006. Ewing's sarcoma: general insights from a rare model.. https://doi.org/10.1016/j.ccr.2006.05.003

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