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PubMed · 16751092

Sorting out Toll signals.

Katherine A Fitzgerald·Zhijian J Chen
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Abstract

Upon recognition of microbial products, Toll-like receptors (TLRs) recruit distinct combinations of adaptors to induce TLR-specific gene expression. In this issue, Kagan and Medzhitov (2006) demonstrate that the adaptor TIRAP/Mal localizes to the plasma membrane by binding to phosphatidylinositol 4,5-bisphosphate (PIP2). This binding recruits a key adaptor MyD88 to TLR4, suggesting that there is crosstalk between the TLR signaling pathway and phospholipid metabolism.

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Adaptor Proteins, Signal TransducingAnimalsHumansMembrane GlycoproteinsMembrane LipidsMyeloid Differentiation Factor 88Phosphatidylinositol 4,5-DiphosphatePhospholipidsProtein TransportReceptors, Interleukin-1Signal TransductionToll-Like Receptor 4Toll-Like ReceptorsCommentJournal ArticleReview

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Katherine A Fitzgerald, Zhijian J Chen. 2006-06-02. Sorting out Toll signals.. https://doi.org/10.1016/j.cell.2006.05.014

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