Bone formation: The nuclear matrix reloaded.

Debra L Ellies; Robb Krumlauf

doi:10.1016/j.cell.2006.05.022

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Bone formation: The nuclear matrix reloaded.

Debra L Ellies·Robb Krumlauf

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Abstract

In this issue of Cell, Grosschedl and colleagues (Dobreva et al., 2006) report that the nuclear matrix protein Satb2 represses Hoxa2 expression and acts with other regulatory proteins to promote osteoblast differentiation. This work suggests a molecular mechanism that enables the integration of patterning and differentiation during bone formation.

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Animals Body Patterning Bone and Bones Cell Differentiation Gene Expression Regulation, Developmental Homeodomain Proteins Humans Matrix Attachment Region Binding Proteins Mesenchymal Stem Cells Neural Crest Nuclear Matrix Osteoblasts Osteogenesis Transcription Factors Journal Article Review Comment

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Debra L Ellies, Robb Krumlauf. 2006-06-02. Bone formation: The nuclear matrix reloaded.. https://doi.org/10.1016/j.cell.2006.05.022

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