Single-molecule detection sensitivity using planar integrated optics on a chip.

Dongliang Yin; David W Deamer; Holger Schmidt; John P Barber; Aaron R Hawkins

doi:10.1364/ol.31.002136

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Single-molecule detection sensitivity using planar integrated optics on a chip.

Dongliang Yin·David W Deamer·Holger Schmidt·John P Barber·Aaron R Hawkins

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Abstract

We present a fully planar integrated optical approach to single-molecule detection based on microfabricated planar networks of intersecting solid and liquid-core waveguides. We study fluorescence from dye molecules in liquid-core antiresonant reflecting optical waveguides, and demonstrate subpicoliter excitation volumes, parallel excitation through multiple pump waveguides, and single-molecule detection sensitivity. Integrated silicon photonics combined with single-molecule detection in solution create a compact, robust, and sensitive platform that has applications in numerous fields ranging from atomic physics to the life sciences.

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Biopolymers Equipment Design Equipment Failure Analysis Lab-On-A-Chip Devices Microchip Analytical Procedures Microscopy, Fluorescence Molecular Probe Techniques Optics and Photonics Reproducibility of Results Sensitivity and Specificity Spectrometry, Fluorescence Systems Integration Journal Article

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Dongliang Yin, David W Deamer, Holger Schmidt, John P Barber, Aaron R Hawkins. 2006-07-15. Single-molecule detection sensitivity using planar integrated optics on a chip.. https://doi.org/10.1364/ol.31.002136

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