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PubMed · 16796519

Larvicidal diterpenes from Pterodon polygalaeflorus.

M C De Omena·E S Bento·J E De Paula·A E G Sant'Ana
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Abstract

Ethanolic extract from seeds of Pterodon polygalaeflorus (Benth) has been shown to possess significant larvicidal activity against the mosquito Aedes aegypti. Bioassay-guided fractionation of the extract led to the isolation and characterization of the know diterpenoid furans 6alpha-hydroxyvouacapan-7beta,17beta-lactone (1), 6alpha,7beta-dihydroxyvouacapan- 17beta-oic acid (2) and methyl 6alpha,7beta-dihydroxyvouacapan-17beta-oate (3). The structures were established from infrared (IR), ultraviolet (UV), 1H-nuclear magnetic resonance (NMR), 13C-NMR, and mass spectral data: full NMR assignments are presented for compounds 1-3 and the diacetyl derivative of 3. Compounds 1-3 exhibited LC50 values of 50.08, 14.69, and 21.76 microg/mL against fourth-instar Aedes aegypti larvae.

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AedesAnimalsBiological AssayDiterpenesFabaceaeInsecticidesLarvaMagnetic Resonance SpectroscopyPest Control, BiologicalPlant ExtractsSeedsJournal ArticleResearch Support, Non-U.S. Gov't

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M C De Omena, E S Bento, J E De Paula, A E G Sant'Ana. 2006. Larvicidal diterpenes from Pterodon polygalaeflorus.. https://doi.org/10.1089/vbz.2006.6.216

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