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Complement activation by sulfonated poly(ethylene glycol)-acrylate copolymers through alternative pathway.

Hong Seok Jang·Kyu Eun Ryu·Woong Shick Ahn·Heung Jae Chun·Hyung Dal Park·Ki Dong Park·Young Ha Kim
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Abstract

Previously, novel poly(ethylene glycol) (PEG) and sulfonated PEG acrylate (PEG-SO(3)A/OA) copolymers were prepared as coating and/or blending materials for biomedical applications. Surfaces modified with copolymers exhibited increased anti-coagulation properties and decreased plasma adsorption level due to increased hydrophilic properties and reorientation characteristics of PEG/PEG-SO(3)A chains in water phase. As continuation study, anti-complement effects of PEG-SO(3)/OA copolymers were investigated in vitro, and compared with those of low-density polyethylene (LDPE) and PEG/OA. C3 activation by PEG-SO(3)/OA samples was lower than that by PEG/OA samples, which was attributed to decreased surface nucleophile level of samples. PEG-SO(3)/OA samples increased inhibition of Bb production, resulting in decreased C5 activation. Owing to reduced activations of C3 and C5, PEG-SO(3)/OA samples markedly decreased SC5b-9 levels in plasma.

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AcrylatesBiocompatible MaterialsCoated Materials, BiocompatibleComplement C5aComplement Membrane Attack ComplexComplement Pathway, AlternativeHumansIn Vitro TechniquesMaterials TestingMolecular StructurePolyethylene GlycolsJournal ArticleResearch Support, Non-U.S. Gov't

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Hong Seok Jang, Kyu Eun Ryu, Woong Shick Ahn, Heung Jae Chun, Hyung Dal Park, Ki Dong Park, Young Ha Kim. 2006-05-02. Complement activation by sulfonated poly(ethylene glycol)-acrylate copolymers through alternative pathway.. https://doi.org/10.1016/j.colsurfb.2006.03.024

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PubMed2007

The effect of finishing and polishing procedures on the surface roughness of composite resin materials.

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