Spike timing-dependent plasticity: from synapse to perception.

Yang Dan; Mu-Ming Poo

doi:10.1152/physrev.00030.2005

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Spike timing-dependent plasticity: from synapse to perception.

Yang Dan·Mu-Ming Poo

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Abstract

Information in the nervous system may be carried by both the rate and timing of neuronal spikes. Recent findings of spike timing-dependent plasticity (STDP) have fueled the interest in the potential roles of spike timing in processing and storage of information in neural circuits. Induction of long-term potentiation (LTP) and long-term depression (LTD) in a variety of in vitro and in vivo systems has been shown to depend on the temporal order of pre- and postsynaptic spiking. Spike timing-dependent modification of neuronal excitability and dendritic integration was also observed. Such STDP at the synaptic and cellular level is likely to play important roles in activity-induced functional changes in neuronal receptive fields and human perception.

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Yang Dan, Mu-Ming Poo. 2006. Spike timing-dependent plasticity: from synapse to perception.. https://doi.org/10.1152/physrev.00030.2005

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