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A born-type approximation method for bioluminescence tomography.

Wenxiang Cong·Kumar Durairaj·Lihong V Wang·Ge Wang
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Abstract

In this paper, we present a Born-type approximation method for bioluminescence tomography (BLT), which is to reconstruct an internal bioluminescent source from the measured bioluminescent signal on the external surface of a small animal. Based on the diffusion approximation for the photon propagation in biological tissue, this BLT method utilizes the Green function to establish a linear relationship between the measured bioluminescent signal and the internal bioluminescent source distribution. The Green function can be modified to describe a heterogeneous medium with an arbitrary boundary using the Born approximation. The BLT reconstruction is formulated in a linear least-squares optimization framework with simple bounds constraint. The performance of this method is evaluated in numerical simulation and phantom experiments.

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AlgorithmsComputer SimulationDiffusionImage EnhancementImage Interpretation, Computer-AssistedLeast-Squares AnalysisLuminescent MeasurementsPhantoms, ImagingReproducibility of ResultsSensitivity and SpecificityTomography, OpticalJournal ArticleResearch Support, N.I.H., Extramural

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Wenxiang Cong, Kumar Durairaj, Lihong V Wang, Ge Wang. 2006. A born-type approximation method for bioluminescence tomography.. https://doi.org/10.1118/1.2168293

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