Atherosclerosis as a risk factor for benign prostatic hyperplasia.

Andreas P Berger; Georg Bartsch; Martina Deibl; Hannes Alber; Otmar Pachinger; Gernot Fritsche; Barbara Rantner; Gustav Fraedrich; Leo Pallwein; Fritz Aigner; Wolfgang Horninger; Ferdinand Frauscher

doi:10.1111/j.1464-410x.2006.06400.x

PubMed · 16879445

Atherosclerosis as a risk factor for benign prostatic hyperplasia.

Andreas P Berger·Georg Bartsch·Martina Deibl·Hannes Alber·Otmar Pachinger·Gernot Fritsche·Barbara Rantner·Gustav Fraedrich·Leo Pallwein·Fritz Aigner·Wolfgang Horninger·Ferdinand Frauscher

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Abstract

OBJECTIVES: To evaluate the relationship between clinical benign prostatic hyperplasia (BPH) and atherosclerosis, using colour Doppler ultrasonography (CDUS) and symptom scores. PATIENTS, SUBJECTS AND METHODS: CDUS was used to evaluate prostatic vascularity in four groups of men, comprising young healthy subjects, patients presenting with coronary artery disease (CAD), diabetes mellitus, or peripheral arterial occlusive disease (PAOD). Resistive index (RI) measurements and computer-assisted quantification of colour pixel density (CPD) were used to objectively evaluate perfusion. The International Prostate Symptom Score (IPSS) and the International Index of Erectile Function were used to quantify symptoms. RESULTS: In diabetic patients and men with PAOD, perfusion of the transition zone (TZ) of the prostate was significantly lower (P < 0.001) and the RI of the TZ was significantly higher (P < 0.001) than in healthy controls and men with CAD. In diabetics and men with PAOD, the mean prostate volume was greater than in healthy controls and men with CAD. The IPSS in patients with vascular damage (diabetes, PAOD) was significantly worse than in the control group. CONCLUSIONS: The significantly lower CPD and higher RI values of the TZ in patients with vascular disease than in healthy subjects support the hypothesis that an age-related impairment of blood supply to the prostate has a key role in the development of BPH.

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Aged Atherosclerosis Cohort Studies Coronary Disease Diabetes Mellitus, Type 2 Humans Male Middle Aged Peripheral Vascular Diseases Prostate Prostatic Hyperplasia Risk Factors Ultrasonography Journal Article

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Andreas P Berger, Georg Bartsch, Martina Deibl, Hannes Alber, Otmar Pachinger, Gernot Fritsche, Barbara Rantner, Gustav Fraedrich, Leo Pallwein, Fritz Aigner, Wolfgang Horninger, Ferdinand Frauscher. 2006-07-28. Atherosclerosis as a risk factor for benign prostatic hyperplasia.. https://doi.org/10.1111/j.1464-410x.2006.06400.x

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