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PubMed · 16886083

Microwave-assisted cyclic amidine synthesis using TiCl4.

Malik Hellal·Frédéric Bihel·Alexandre Mongeot·Jean-Jacques Bourguignon
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Abstract

Microwave-assisted treatment of various heterocyclic amides (benzodiazepinone, phthalazone) with TiCl(4) in the presence of primary or secondary amines provides the corresponding amidines. In addition to the interest of the microwaves for this reaction, our study highlights the higher reactivity of the cyclic acetamide moiety compared to the cyclic benzamide moiety towards this TiCl(4)-mediated reaction.

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AmidinesMagnetic Resonance SpectroscopyMicrowavesSpectrometry, Mass, Electrospray IonizationTitaniumJournal Article

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Malik Hellal, Frédéric Bihel, Alexandre Mongeot, Jean-Jacques Bourguignon. 2006-07-12. Microwave-assisted cyclic amidine synthesis using TiCl4.. https://doi.org/10.1039/b607095g

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