Molecular networks orchestrating GALT development.

D Finke; D Meier

doi:10.1007/3-540-30657-9_2

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PubMed · 16922085

Molecular networks orchestrating GALT development.

D Finke·D Meier

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Abstract

During evolution, the development of secondary lymphoid organs has evolved as a strategy to promote adaptive immune responses at sites of antigen sequestration. Mesenteric lymph nodes (LNs) and Peyer's patches (PPs) are localized in proximity to mucosal surfaces, and their development is coordinated by a series of temporally and spatially regulated molecular events involving the collaboration between hematopoietic, mesenchymal, and, for PPs, epithelial cells. Transcriptional control of cellular differentiation, production of cytokines as well as adhesion molecules are mandatory for organogenesis, recruitment of mature leukocytes, and lymphoid tissue organization. Similar to fetal and neonatal organogenesis, lymphoid tissue neoformation can occur in adult individuals at sites of chronic stimulation via cytokines and TNF-family member molecules. These molecules represent new therapeutic targets to manipulate the microenvironment during autoimmune diseases.

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Animals Biological Evolution Humans Immunity, Mucosal Lymph Nodes Organogenesis Peyer's Patches Journal Article Research Support, Non-U.S. Gov't Review

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D Finke, D Meier. 2006. Molecular networks orchestrating GALT development.. https://doi.org/10.1007/3-540-30657-9_2

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