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A transcriptional logic for nuclear reprogramming.

Kit T Rodolfa·Kevin Eggan
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Abstract

Limitations on a differentiated cell's pluripotency can be erased by nuclear transfer or by fusion with embryonic stem cells, but attempts to recapitulate this process of nuclear reprogramming by molecular means have failed. In this issue of Cell, Takahashi and Yamanaka (2006) take a rational approach to identifying a suite of embryonic transcription factors whose overexpression restores pluripotency to adult somatic cells.

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AnimalsCell NucleusEmbryo, MammalianHybrid CellsMicePluripotent Stem CellsTranscription FactorsTranscription, GeneticTransgenesCommentJournal Article

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Kit T Rodolfa, Kevin Eggan. 2006-08-25. A transcriptional logic for nuclear reprogramming.. https://doi.org/10.1016/j.cell.2006.08.009

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