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Microfluidic technologies for MALDI-MS in proteomics.

Don L DeVoe·Cheng S Lee
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Abstract

The field of microfluidics continues to offer great promise as an enabling technology for advanced analytical tools. For biomolecular analysis, there is often a critical need to couple on-chip microfluidic sample manipulation with back-end MS. Though interfacing microfluidics to MS has been most often reported through the use of direct ESI-MS, there are compelling reasons for coupling microfluidics to MALDI-MS as an alternative to ESI-MS for both online and offline analysis. The intent of this review is to provide a summary of recent developments in the integration of microfluidic systems with MALDI-MS, with an emphasis on applications in proteomics. Key points are summarized, followed by a review of relevant technologies and a discussion of outlook for the field.

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MicrofluidicsProteinsProteomicsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationJournal ArticleReview

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Don L DeVoe, Cheng S Lee. 2006. Microfluidic technologies for MALDI-MS in proteomics.. https://doi.org/10.1002/elps.200600224

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